Food-Effect on PK and PD of Single Oral Dose of CJ-12420 in Healthy Male Subjects

Exclusion Criteria

• •Subjects will be excluded from the study if there is evidence of any of the following criteria: Last three criteria will be applied ONLY to PD/PK group.
• •History of clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary,immunologic, psychiatric, musculoskeletal or cardiovascular disease or any other condition, which, in the opinion of the Investigator, would jeopardize the safety of the subject or impact the validity of the study results
• •History of allergy or sensitivity to any drug, including any prior serious adverse reaction to PPIs (e.g. omeprazole, rabeprazole, lansoprazole)
• •History of symptomatic GERD, erosive esophagitis, duodenal ulcer, gastric ulcer, Barrett's esophagus or Zollinger-Ellison syndrome, previous positive H. pylori
• •The following criteria will be applied ONLY to PD/PK group
• •H.pylori positive, as determined by the urea breath test
• •Urine cotinine test positive
• •Subject who were unable to be applicable for pH meter catheter