Minocycline in Acute Spinal Cord Injury (MASC)

Exclusion Criteria

• •History of systemic lupus erythematosus (SLE)
• •Pre-existing hepatic or renal disease
• •Tetracycline hypersensitivity
• •Pregnancy or breast feeding
• •Isolated radicular motor deficit
• •Significant leucopenia (white blood cell count \< 1⁄2 times the lower limit of normal) at screening
• •Elevated liver function tests (AST, ALT, alkaline phosphatase, or total bilirubin \> 2 times the upper limit of normal) at screening
• •Presence of systemic disease that might interfere with patient safety, compliance or evaluation of the condition under study (e.g. insulin-dependent diabetes, Lyme disease, clinically significant cardiac disease, HIV, HTLV-1)
• •Associated traumatic conditions interfering with informed consent or outcome assessment (e.g. closed head injury, liver contusion)
• •Known uncorrected severe coronary artery disease or evidence of active coronary ischemia (ECG changes, positive Troponin) will be excluded, as they may not tolerate the standardized protocol for hemodynamic management