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Keep this study
Lead
Hennepin Healthcare Research Institute
This study is a randomized controlled trial of etomidate versus ketamine during rapid sequence intubation (RSI). RSI refers to the process by which patients who require emergency airway management undergo sedation and paralysis prior to insertion of an endotracheal tube(airway tube). Patients who require intubation will be randomized to have intubation performed with either ketamine or etomidate. All other care will be at the discretion of the treating physicians. The purpose of this study is to compare the efficacy and safety of ketamine and etomidate during rapid sequence intubation.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 years of age
Undergoing rapid sequence intubation (RSI) in the Emergency Department
You may not be if
Known contraindication to ketamine or etomidate
Patient has a condition in which an increase in heart rate or blood pressure would be hazardous, as judged by the treating physician
Patient is known or suspected of having increased intracranial pressure, based on the history and physical examination performed by the treating physician.
Females of child-bearing age, defined as 18-50 years, who do not have a documented pregnancy test in this institution confirming that they are not pregnant or who do not have a confirmed surgical procedure preventing pregnancy, i.e., tubal ligation, hysterectomy. The timing of the pregnancy test at which the investigative team will consider a subject to be non-pregnant is a documented negative test during current hospitalization or upon direct transfer from outside institution during current illness.
Patient declines participation in the trial by wearing a bracelet marked "KvE declined"
Prisoner
Clareo Health | Ketamine Versus Etomidate for Rapid Sequence Intubation