Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

Exclusion Criteria

• •Use of one of the following methods of birth control by female participants: barrier methods (diaphragm or condoms with spermicidal or both), surgical sterilization, use of an intra-uterine contraceptive device, or complete abstinence from sexual intercourse.
• •Individuals must live within a 50-mile radius of our research program and have reliable transportation.
• •Individuals must consent to remain abstinent from all drugs of abuse (except nicotine) for 72 hours immediately prior to CTRC inpatient admission.
• •Individuals must consent to random assignment to one of three study groups (the two propranolol-treated groups or the placebo-treated group).
• •Women who are pregnant, nursing or of childbearing potential and not practicing an effective means of birth control.
• •Individuals with evidence of or a history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal, or neurological disease including diabetes, as these conditions may affect heart rate or skin conductance measurement.
• •Individuals with significant liver impairment as propranolol is hepatically metabolized.
• •Individuals with a history of or current psychotic disorder, current major depressive disorder, bipolar affective disorder or a severe anxiety disorder as these may impact cue reactivity.
• •Individuals currently taking anti-arrythmic agents, psychostimulants or any other agents known to interfere with heart rate and skin conductance monitoring.
• •Known or suspected hypersensitivity to propranolol.
• •Individuals taking medications that could adversely interact with the study medication, including, but not limited to albuterol, insulin, or significant inhibitors of CYP2D6.
• •Individuals with bronchial asthma or chronic obstructive pulmonary disease, as the use of propranolol is contraindicated in these individuals.
• •Individuals with any physical condition or disability that would compromise optimal sensory processing of the cues (e.g., blindness).