Baclofen Effects in Cigarette Smokers

Exclusion Criteria

• •History of head trauma or injury causing loss of consciousness, lasting more than five (5) minutes or associated with skull fracture or inter-cranial bleeding or abnormal MRI.
• •Current Diagnostic and Statistical Manual-IV (DSM-IV) Axis I diagnoses other than nicotine dependence.
• •Presence of magnetically active irremovable prosthetics, plates, pins, permanent retainer, bullets, etc. (unless a radiologist confirms that it's presence is unproblematic). An x-ray may be obtained to determine eligibility given the possibility of a foreign body.
• •History of psychosis.
• •Claustrophobia or other medical condition preventing subject from lying in the MRI for approximately one (1) hour.
• •Current diagnosis of or treatment within the last 3 months for alcohol dependence.
• •Current use of any smoking cessation treatments such as Zyban, Chantix, Wellbutrin, patch, gum, inhaler, electronic cigarettes, herbal preparations.
• •Vision problems that cannot be corrected with glasses.
• •Weight exceeding 300 pounds \[Imaging data acquisition is impaired with high weight individuals\].
• •History of stroke.