Contact Lens Comfort Relative to Meibomian Gland Status

Exclusion Criteria

• •1. Wear Acuvue Oasys with Hydraclear Plus on an extended wear basis.
• •2. Wear Acuvue Oasys with Hydraclear Plus for astigmatism.
• •3. History of epithelial herpes simplex keratitis (dendritic keratitis); vaccinia, active or recent varicella, viral disease of the cornea and/or conjunctiva; chronic bacterial disease of the cornea and/or conjunctiva; mycobacterial infection of the eye; and/or fungal disease of the eye.
• •4. Use of concomitant ocular medications during the study period. Topical artificial tears or contact lens lubricants are allowed, but no instillation on the day of examinations.
• •5. Any systemic disease, autoimmune disease, or use of medications, which may interfere with contact lens wear.
• •6. Subjects using medications influencing tear production such as steroids, immunosuppressive agents and/or anti-cholinergics (e.g. cold and allergy medications, tricyclic antidepressants) for treatment of autoimmune connective tissue disease may not be enrolled in this study if they have not been on a stable dosing regimen for 30 days prior to the Eligibility Visit. Subjects may use birth control medications since there is inconclusive evidence relative to the influence on tear film.
• •7. Any infectious disease (e.g. Hepatitis, tuberculosis) or a contagious immunosuppressive disease (e.g. HIV, by self report).
• •8. Subjects reporting discomfort at screening visit related to fit or care system abnormalities (both determined by the investigator), ocular conditions such as conjunctival infections, iritis.
• •9. Currently pregnant or lactating (subjects who become pregnant during the study will be discontinued).
• •10. Any ocular or systemic allergies or diseases that may interfere with contact lens wear.
• •11. Entropion, ectropion, extrusion, chalazia, recurrent styes, glaucoma, history of recurrent corneal erosion,aphakia, or moderate or above corneal distortion by keratometry.
• •12. Any previous, or planned, ocular or intraocular surgery (radial keratotomy, LASIK, ETC.)
• •13. Any grade 3 or greater slit lamp findings (e.g. edema, corneal neovascularization, corneal staining, tarsal abnormalities, conjunctival injection) on the FDA classification scale, any previous history or signs of a contact lens-related corneal inflammatory event (e.g. past peripheral ulcer or round peripheral scar), or any other ocular abnormality that may contraindicate contact lens wear.
• •14. Any corneal distortion resulting from previous hard or rigid gas permeable contact lens wear.
• •15. Monovision or multi-focal contact lens correction
• •16. Participation in any contact lens or lens care product clinical trial within 30 days prior to study enrollment
• •17. History of binocular vision abnormality or strabismus
• •18. History of serious mental illness
• •19. History of seizures