Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes

Exclusion Criteria

• •1. Any comorbid condition associated with inflammation, insulin resistance, or dyslipidemia,
• •2. Tobacco use,
• •3. Pregnancy,
• •4. Steroid use,
• •5. Scheduled physical activity \>3 days a week,
• •6. Angina or any other cardiovascular or pulmonary disease,
• •7. History of chronic obstructive pulmonary disease or asthma,
• •8. Systolic blood pressure \>190 at rest or \>250 with exercise, or
• •9. Diastolic pressure \>95 at rest, or \>105 with exercise,
• •10. Proteinuria (urine protein \>200 mg/dl), or
• •11. Creatinine \> 2 mg/dl, suggestive of severe renal disease,
• •12. Severe Proliferative retinopathy,
• •13. Niacin treatment,
• •14. History of peptic ulcers,
• •15. History of hereditary angioedema, and
• •16. C1 esterase deficiency.