Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma

Inclusion Criteria

• •Research participants enrolled are patients with an indication to be considered for HSCT, who are diagnosed with intermediate grade B-cell NHL (e.g., DLBCL, MCL or transformed NHL), and that have either recurrence/progression following prior therapy, or verification of high-risk disease in first remission
• •Karnofsky performance status of \>= 70% and a life expectancy \>= 16 weeks at time of enrollment
• •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation; should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• •City of Hope (COH) pathology review confirms that research participant's diagnostic material is consistent with the history of intermediate grade B-cell NHL (e.g., DLBCL, MCL or transformed NHL)
• •Negative serum pregnancy test for women of childbearing potential
• •Research participant has an indication to be considered for autologous stem cell transplantation
• •All patients must have the ability to understand and the willingness to sign a written informed consent
• •ELIGIBILITY TO UNDERGO AUTOLOGOUS MYELOABLATIVE TRANSPLANTATION WITH HEMATOPOETIC PROGENITOR CELL (HPC)A RESCUE
• •Research participant meets all standard clinical parameters for candidates of autologous transplant as described in the current COH Hematopoietic Cell Transplant Standard Operating Policies, Procedures and Protocols
• •Patient Evaluation \& Selection or Deferral for hematopoietic cell transplantation (HCT)
• •Research participant is scheduled to receive a standard chemotherapy-based conditioning regimen, such as cyclophosphamide, carmustine, etoposide (CBV) or carmustine, etoposide, cytarabine, melphalan (BEAM)
• •Research participant has a cryopreserved unselected HPCA product of at least 3 x 10\^6/kg CD34+ cells
• •Research participant does not have evidence of disease progression after salvage therapy
• •ELIGIBILITY CRITERIA AT TIME OF INFUSION OF GENETICALLY MODIFIED AUTOLOGOUS T CELLS
• •Research participant has a released cryopreserved T cell product
• •Research participant has undergone an autologous HPC(A) procedure
• •Not requiring supplemental oxygen or mechanical ventilation, oxygen saturation of 90% or higher on room air
• •Not requiring pressor support, not having symptomatic cardiac arrhythmias
• •Lack of acute renal failure/requirement for dialysis, as evidenced by creatinine \< 1.6 - Total bilirubin =\< 5.0
• •Research participant without clinically significant encephalopathy/new focal deficits
• •No clinical evidence of uncontrolled active infections process