A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers

Exclusion Criteria

• •Significant history or clinical manifestation of any significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder
• •History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance
• •History of stomach or intestinal surgery or resection that would alter absorption and/or excretion of orally administered study drugs
• •History of alcoholism or drug addiction within 1 year prior to Check-in
• •History of chronic proton pump inhibitor (PPI) use within 6 months of Check-in, or use of PPIs, H2-receptor antagonists, or antacids within 1 month prior to Check-in and during the entire study
• •Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis
• •History type 1 or 2 diabetes and/or elevated fasting glucose at baseline
• •Malabsorption syndrome or other condition that would interfere with enteral absorption
• •Use of any tobacco- or nicotine containing- products
• •Participation in any other investigational study drug or biologic agent trial in which receipt of an investigational study drug occurred within 5 half-lives or 30 days, whichever is longer to Check-in and during the entire study duration