Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Colorado, Denver
With
American Diabetes Association
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
12–21
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Adolescents 12-21 years of age with type 1 diabetes (defined as having positive antibodies as well as insulin requirement)
2. Willing to consent for participation in study
3. Body Mass Index (BMI) \>5% on growth charts
You may not be if
1. Current use of medications known to affect insulin sensitivity: oral glucocorticoids within 10 days, atypical antipsychotics, immunosuppressant agents, metformin or thiazolidinediones.
2. Currently pregnant or breastfeeding women
3. Use of a thiazolidinedione within 12 weeks
4. Severe illness or Diabetic Ketoacidosis within 60 days
5. Macroalbuminuria
6. Hemoglobin A1c \> 12%
7. Weight \> 136.4 kg or \< 42 kg, BMI \< 5%
8. Creatinine \> 1.2
9. Hemoglobin \< 9
10. Major psychiatric or developmental disorder limiting informed consent
11. Implanted metal devices
12. Inability to tolerate ≥500mg twice a day of metformin
Clareo Health | EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
