Salivary Biomarkers for Sjögren's Syndrome Detection

Inclusion Criteria

• •Ability to give informed consent (Appendix 1).
• •Male or female patients 18 years of age or older.
• •Patients with sicca symptoms as defined in Appendix 2.
• •Must be willing to have a standard physical exam as part of standard clinical care and a complete diagnostic work-up according to the new ACR criteria for ocular staining, labial salivary gland biopsy and serology.
• •Must be willing to have a standard physical exam and complete AECG diagnostic tests as part of standard clinical care (including eye exam, oral exam, salivary gland exam and biopsy).
• •Must be willing to complete a questionnaire (approximately 10 min).
• •Must be willing to donate 1ml of stimulated, whole saliva in 30 minutes or less. If a participant cannot produce 1ml during a 30 min collection period, subject will be unevaluable and will be considered a screen failure and withdrawn from the study.
• •For UMCG only, subject must be willing to have a labial salivary gland biopsy in addition to a parotid biopsy.
• •Must be willing and able to give approximately 8ml of blood.
• •Must be willing to be tested for Hepatitis C, if required