Lead Sponsor

Herzog Hospital

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

•1. age 18-70;
•2. diagnosis of schizophrenia/schizoaffective disorder according to DSM-IV criteria; diagnosis will be made on the basis of SCID interview and information from medical records, previous treating psychiatrists, and family informants;
•3. history of ≥3 months antipsychotic drugs treatment and present stable dose antipsychotic treatment for at last 4 weeks;
•4. fulfillment of Schooler-Kane TD research criteria on a first evaluation performed 2-12 weeks prior to study entrance and on a subsequent evaluation performed prior to allocation to experimental treatment.

•1. meeting criteria for other DSM-IV Axis I diagnoses;
•2. presence of a neurological disorder or history of significant head injury;
•3. substance abuse or alcoholism during entire lifetime;
•4. are judged clinically to be at suicidal or homicidal risk;
•5. female patients who are pregnant or lactating; female patients who are not pregnant or lactating, if sexually active, must be using medically accepted means of contraception.

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