Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Brigham and Women's Hospital
With
National Heart, Lung, and Blood Institute (NHLBI)
Age
18–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Subject selection
Men and women ages 18 to 80 years old
Good health as determined by a medical and psychiatric history and physical examination
An absence of any medical or psychiatric disorders (other than OSA and treated hypertension) that could influence excessive daytime sleepiness
The ability to complete self-rating scales and computer-based testing
Beck Depression Inventory score ≤16
Healthy controls will be excluded with and Epworth Sleepiness Scale (ESS) score \> 10/24, OSA patients will be excluded from randomization with an ESS score \>18/24.
Subjects must agree to abstain from alcohol consumption from the day before and throughout Session 1 and Session 2.
Criteria for OSA patients:
Newly diagnosed with OSA and with no prior exposure to CPAP
Quantified apnea-hypopnea index greater than 5/hr (AHI, defined as the number of apneas and/or hypopneas per hour of sleep)
Subjects must agree to limit alcohol use between Session 1 and Session 2 to one or fewer alcoholic drinks daily or up to 4 drinks weekly
Criteria for Healthy control group:
Subjects will be matched to the obstructive sleep apnea patient group for age, race, body mass index, education and intelligence (WAIS - full scale)
Subgroup selection:
You may not be if
The following classes of antidepressants will be eligible:
Selective serotonin reuptake inhibitors
Serotonin-norepinephrine reuptake inhibitors
Noradrenergic and specific serotonergic antidepressants
Norepinephrine-dopamine reuptake inhibitors
ALL PARTICIPANTS:
Potential participants (OSA patients and controls) are excluded if one or more of the following conditions are found:
Any history of clinically significant, uncontrolled medical or psychiatric condition (treated or untreated), other than OSA and hypertension (self-report)
History of serious heart disease or renal failure (self-report)
History of head injury (self-report)
Inability to type (e.g., physical disability, arthritis) or to exercise
A lifetime history of alcohol, narcotic or any other drug abuse (self-report)
Use of medications, over-the counter drugs or nutritional supplements known to have an effect on sleep, cognition and/or daytime vigilance (self-report)
Female subjects who are pregnant cannot take part in the study. If a female subject becomes pregnant during the study, she will have to stop participation
Presence of any of the following sleep disorders:
* Cheyne-Stokes breathing or central sleep apnea (\> 10% of events central) (screening sleep study)
