Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart

Exclusion Criteria

• •Patient has heart failure due to or associated with uncorrected primary valvular disease, uncorrected thyroid disease, obstructive/hypertrophic cardiomyopathy, pericardial disease, amyloidosis, active myocarditis, or malfunctioning artificial heart valve.
• •Patient is actively on heart transplant list or anticipated to be within 6 months of randomization
• •Patient is receiving any of the following medicines:
• •1. Calcium channel blockers
• •2. Theophylline
• •3. Tricyclic antidepressants
• •4. Monoamine oxidase inhibitors
• •5. β-agonists
• •6. β-adrenergic blocking agent (oral)
• •7. Any investigational cardiovascular medication or involvement in another investigational trial
• •8. Flecainide, encainide, propafenone, sotalol, disopyramide, or amiodarone
• •Patient has a contraindication to β-blockade (eg asthma)
• •Patient has another life-threatening disease with life expectancy \< 2 years due to other illness
• •Patient has active hepatic, renal, hematologic, gastrointestinal, immunologic, endocrine, metabolic, or central nervous system disease which may adversely affect the safety and efficacy of the study drug or life span of the patient
• •Unstable decompensated heart failure (evidence of hypoperfusion, acute pulmonary edema, or hypotension with SBP \< 80 mm Hg)
• •Patient is actively abusing ethanol or illicit drugs within 3 months of randomization
• •Patient has an automatic implantable cardiac defibrillator that has fired within 3 months of randomization
• •Patient has an asymptomatic waking, resting heart rate \< 50 bpm or symptomatic bradycardia \< 60 bpm.
• •Patient has uncontrolled insulin-dependent diabetes mellitus with a history of frequent hypoglycemia episodes
• •Patient has a high degree atrioventricular block (Mobitz Type II or complete heart block)
• •Patient is unable to tolerate magnetic resonance imaging procedures
• •Patient has demonstrated non-compliance with previous medical regimens