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COMPLETEDNA

Randomized-controlled Trial (RCT) on CPAP-withdrawal and Microvascular Function in OSA

The Effects of CPAP-withdrawal on Microvascular Function in Patients With Obstructive Sleep Apnea: A Randomized-controlled Trial

NCT01797653•University of Zurich

View on ClinicalTrials.gov

Summary

Randomized controlled trial (therapeutic vs. placebo CPAP) including 46 patients with obstructive sleep apnea (OSA) to define the physiological effects of continuous positive airway pressure (CPAP) therapy withdrawal on myocardial perfusion and dermal and renal microvascular function during a 2 week period.

Eligibility

Age

20 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Objectively confirmed OSA (at the time of original diagnosis) with an oxygen desaturation index (ODI, =4% dips) of \>20/h and an ESS of \>10.
•Currently \>20/h oxygen desaturations (=4% dips) during an ambulatory nocturnal pulse oximetry performed at the end of a 4-night period without CPAP.
•Treated with CPAP for more than 12 months, minimum compliance 4h per night, AHI\<10 with treatment (according to CPAP machine download data).
•Current ESS \<10.

Exclusion Criteria

•Previous ventilatory failure (awake SpO2 \<93% and PaCO2\>6kPa).
•Unstable, untreated coronary or peripheral artery disease, severe arterial hypertension or hypotension (\>180/110 or \<90/60mmHg)
•Previously diagnosed with Cheyne-Stokes breathing.
•Current professional driver; Any previous sleep related accident.
•Age \<20 or \>75 years at trial entry.
•Acute inflammatory disease

Locations (1)

University Hospital Zurich, Division of Pneumology

Zurich, Canton of Zurich, Switzerland

Key Dates

Start Date

February 1, 2013

Primary Completion Date

December 1, 2013

Completion Date

December 1, 2013

Last Updated

December 23, 2013

Enrollment

ACTUAL participants

Conditions

Obstructive Sleep Apnoea

Interventions

CPAP therapy withdrawal

OTHER

Continue CPAP treatment

PROCEDURE

Clinical Trial of a Rehabilitation Device Based on Electrostimulation for Obstructive Sleep Apnoea

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Obstructive Sleep Apnoea

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COMPLETEDNA

EndoBarrier in Obstructive Sleep Apnoea Study

NCT06376305

Type 2 DiabetesObstructive Sleep Apnoea+1 more

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WITHDRAWN

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 23, 2013Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Randomized-controlled Trial (RCT) on CPAP-withdrawal and Microvascular Function in OSA

Inclusion Criteria

Exclusion Criteria

Clinical Trial of a Rehabilitation Device Based on Electrostimulation for Obstructive Sleep Apnoea

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