History of aspirin use 1-14 days prior to screening

NSAID (ibuprofen, naprosyn, meloxicam, etc) use 1-7 days prior to screening

Inhaled glucocorticoid use 1-7 days prior to screening

Systemic glucocorticoid use 1-14 days prior to screening

History of peptic ulcer disease

Current or recent clinically significant bleeding

Allergy, intolerance or contraindication to aspirin or NSAID use

Thrombocytopenia (platelet count \< 100,000) in 30 days prior to screening visit

Severe hepatic insufficiency

GFR \< 30 mL/min/1.73 m2 in 30 days prior to screening visit

History of aspirin or celecoxib allergy

Elevated INR (\>1.5) in 30 days prior to screening visit

Current diagnosis of malignancy or history of non-skin malignancy in last 5 years

Current use of systemic anticoagulants (e.g., warfarin (Coumadin), enoxaparin (Lovenox), Fondaparinux (Arixtra), dabigatran (Pradaxa))

Diagnosis of COPD

Intake of \> 250 mg of fish oil supplementation daily

Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers