The Fasting II Study

Exclusion Criteria

• •1. Pregnant and/or lactating women and women of child bearing potential who are not using acceptable means of contraception. Women of childbearing potential must be using adequate measures of contraception (as determined by the Principal Investigator) to avoid pregnancy and should be highly unlikely to conceive during the study period. Women of childbearing potential must have a negative pregnancy test at screen.
• •2. Diabetics taking any of the following anti-diabetic medications: insulin, metformin, thiazolidinediones, sulfonylureas, alpha-glucosidase inhibitors, meglitinides, or incretins.
• •3. Prior experience with fasting more than once per month (for 20 hours or more), on average during the last year.
• •4. Very low body mass index (BMI) (\<18.5 kg/m2) or high BMI (\>40 kg/m2).
• •5. Individuals who are nutritionally compromised, as assessed by the Principal Investigator.
• •6. Any immunodeficiency or prior solid organ transplantation or renal disease.
• •7. Participation in any other clinical trials involving investigational or marketed products within 30 days prior to entry in the study.
• •8. Other conditions that in the opinion of the Principal Investigator may increase risk to the subject and/or compromise the quality of the clinical trial.