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An Open-label, Biomarker Study of Arsenic Trioxide for the Treatment of Patients With Basal Cell Carcinoma
This pilot clinical trial studies arsenic trioxide in treating patients with basal cell carcinoma. Drugs used in chemotherapy, such as arsenic trioxide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stop them from dividing
PRIMARY OBJECTIVES: I. To determine whether administration of arsenic trioxide (ATO) to patients with basal cell carcinoma is associated with a reduction in Gli messenger ribonucleic acid (mRNA) and protein levels in tumor biopsy samples, when compared to baseline levels. SECONDARY OBJECTIVES: I. To determine whether there is evidence of tumor size reduction of ATO against basal cell carcinoma in humans. OUTLINE: Patients receive arsenic trioxide intravenously (IV) over 2 hours on days 1-5. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Stanford University Medical Center
Stanford, California, United States
Start Date
April 1, 2013
Primary Completion Date
November 1, 2013
Completion Date
November 1, 2015
Last Updated
June 8, 2018
5
ACTUAL participants
arsenic trioxide
DRUG
Lead Sponsor
Stanford University
Collaborators
NCT02324608
NCT00089180
Data Source & Attribution
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