RISE Adult Medication Study

Exclusion Criteria

• •1. Underlying disease likely to limit life span and/or increase risk of intervention or an underlying condition that is likely to limit ability to participate in outcomes assessment
• •2. An underlying disease that affects glucose metabolism other than type 2 diabetes
• •3. Taking medications that affect glucose metabolism, or has an underlying condition that is likely to require such medications
• •4. Active infections
• •5. Renal disease (serum creatinine \>1.4 mg/dl for men; \>1.3 mg/dl for women) or serum potassium abnormality (\<3.4 or \>5.5 mmol/l)
• •6. Anemia (hemoglobin \<11 g/dl in women, \<12 g/dl in men) or known coagulopathy
• •7. Cardiovascular disease, including uncontrolled hypertension. Participants must be able to safely tolerate administration of intravenous fluids required during clamp studies.
• •8. History of conditions that may be precipitated or exacerbated by a study drug:
• •1. Pancreatitis
• •2. Serum alanine transaminase (ALT) more than 3 times the upper limit of normal
• •3. Excessive alcohol intake
• •4. Suboptimally treated thyroid disease
• •5. Medullary carcinoma of the thyroid or MEN-2 (in participant or a family history)
• •6. Hypertriglyceridemia (\>400 mg/dl despite treatment)
• •9. Conditions or behaviors likely to affect the conduct of the RISE Study
• •1. Unable or unwilling to give informed consent
• •2. Unable to adequately communicate with clinic staff
• •3. Another household member is a participant or staff member in RISE
• •4. Current, recent or anticipated participation in another intervention research project that would interfere with any of the interventions/outcomes in RISE
• •5. Weight loss of \>5% in past three months for any reason other than post-partum weight loss. Participants taking weight loss drugs or using preparations taken for intended weight loss are excluded.
• •6. Likely to move away from participating clinics in next two years
• •7. Women of childbearing potential who are unwilling to use adequate contraception
• •8. Current (or anticipated) pregnancy and lactation.
• •9. Major psychiatric disorder that, in the opinion of clinic staff, would impede the conduct of RISE
• •10. Additional conditions may serve as criteria for exclusion at the discretion of the local site.