Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Texas Southwestern Medical Center
With
American Urogynecologic Society Foundation Astellas Research Award
Age
40–70
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
Women, still with uterus, planning total hysterectomy as part of surgical repair for pelvic organ prolapse
Symptomatic anterior and/or apical vaginal prolapse greater than or equal to Stage 2 (i.e., bulge extends to at least 1 cm of the hymen or beyond)
Women between 1 and 10 years after menopause. Menopause is defined as one year of amenorrhea or surgical ovariectomy.
Age 40-70 years old
No estrogen replacement therapy in the last 1 month
Physically capable of daily application of vaginal cream
You may not be if
BMI \>35
Prior surgical repair of prolapse involving the vaginal cuff.
Prior total hysterectomy
Premenopausal or postmenopausal \>10 years
Prior steroid hormone replacement therapy of duration \>1 month (oral or vaginal estrogen, testosterone or corticosteroids)
History of connective tissue disease (Ehlers-Danlos, Marfan, etc)
History of vaginal radiation
Contraindications for estrogen replacement therapy (current, or history of, spontaneous deep vein thrombosis, stroke, coronary artery disease, breast or endometrial cancer)
Concurrent use of steroid cream for treatment of Lichen sclerosis
Recent history (within last month) of vaginal infection or vaginitis
