This study will follow HIV positive and negative subjects annually for 5 years. The aims of this study include:
* to describe the pathology underlying low bone mineral density
* to assess the relationship between low bone mineral density and antiretroviral therapy exposure
* to assess the relationship between low bone mineral density and vitamin D /PTH status and/or markers of bone metabolism
* to assess the relationship between osteopenia and subsequent changes in bone mineral density and markers of bone metabolism
* to assess the validity of the currently available fracture risk assessment tool in predicting fractures in HIV positive populations
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
age \>18 years
be able to provide written, informed consent
be able to attend the research centre in a fasting state and undergo DEXA scanning
You may not be if
Subjects on bisphosphonate therapy at screening
Pregnant or breastfeeding female subjects
Subjects with a previous clinical history of primary hyperthyroidism or HIV negative subjects with elevated parathyroid hormone at screening
HIV-negative subjects with a prior history of osteoporosis
