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Keep this study
Lead
Augusta University
The overall goals of this proposal are to provide mechanistic evidence that oxidative stress contributes to 1) endothelial dysfunction and 2) exercise intolerance in patients with CF. This study consists of two separate sub-studies, or protocols. Protocol 1: AOC tested the effect of an antioxidant cocktail (AOC) on endothelial function at rest and during exercise in CF patients. Protocol 2: BH4 tested the effect of tetrahydrobiopterin (BH4) on endothelial function at rest and during exercise in CF patients.
Age
7–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Diagnosis of CF and healthy controls
Men and women (\> 18 yrs. old)
Boys and girls (7 -17 yrs. old)
FEV1 percent predicted \> 30%
Resting oxygen saturation (room air) \>90%
Patients with or without CFRD
Traditional CF-treatment medications
Ability to perform reliable/reproducible PFTs
Clinically stable for 2 weeks (no exacerbations or need for antibiotic treatment within 2 weeks of testing or major change in medical status)
