Clinical Pharmacology Study of MP-424

Exclusion Criteria

• •Subjects with a BMI of \<18.5 or \>25.0, or body weight of \<50kg at prior examination
• •Subjects who have had surgery that is known to affect gastrointestinal absorption of drugs (except for appendectomy and hernia surgery)
• •Subjects who have had any evidence of cardiac disease at prior examination or who have a previous history of cardiac disease
• •Subjects who are positive for HBs antigen, serologic tests for syphilis, HCV antibody, or HIV antibody at prior examination
• •Subjects who have experienced symptoms of alcohol abuse or excessive alcohol ingestion
• •Subjects who test positive on urinalysis for drug use (amphetamine, benzodiazepine, barbiturates, cannabinoid, cocaine, opiates, and methadone) at prior examination
• •Subjects who do not agree to use a physical contraceptive method during the study period
• •Subjects who do not agree to use contraceptive methods for 90 days after final administration of the study drug
• •Subjects who have consumed grapefruit, Seville orange, star fruit, cranberry, or any processed food containing these fruits within 7 days before the commencement of study drug administration
• •Subjects who have consumed health foods containing St John's Wort within 2 weeks before study drug administration