Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma

Exclusion Criteria

• •1. Women who are pregnant or lactating. Women of child-bearing potential (WOCBP) and fertile men with a WOCBP partner, not using adequate birth control.
• •2. Patients with islet cell tumors or other non-epithelial cell malignancies of the pancreas.
• •3. Patients with known CNS (or leptomeningeal) metastases not controlled by prior surgery or radiotherapy, or patients with symptoms suggesting CNS involvement for which treatment is required.
• •4. Patients with an active second malignancy within the last 2 years with the exception of:
• •* Treated, non-melanoma skin cancers
• •* Treated CIS of the breast or cervix
• •* Controlled, superficial bladder carcinoma
• •* T1a or b prostate carcinoma involving \< 5% of resected tissue and PSA within normal limits (WNL) since resection
• •5. Patients with any of the following hematologic abnormalities at baseline:
• •* Hemoglobin \< 9.0 g/dL
• •* Absolute neutrophil count (ANC) \< 1,500 per mm3
• •* Platelet count \< 100,000 per mm3
• •6. Patients with any of the following serum chemistry abnormalities at baseline:
• •* Total bilirubin \> 1.5× the ULN for the institution, unless considered due to Gilbert's Syndrome
• •* AST or ALT \> 3× the ULN for the institution (\> 5× ULN if due to hepatic involvement by tumor)
• •* Serum albumin \< 2.5 g/dL
• •* Serum creatinine \> 1.5× ULN (or a calculated creatinine clearance \< 60 mL/min/1.73 m2)
• •7. Patients with a significant cardiovascular disease or condition, including:
• •* Congestive heart failure (CHF) currently requiring therapy
• •* Need for anti-arrhythmic therapy for a ventricular arrhythmias
• •* Severe conduction disturbances
• •* Angina pectoris requiring therapy
• •* Left ventricular ejection fraction (LVEF) \< 50% by MUGA or echocardiogram
• •* QTcF interval \> 450 msec (males) or \> 470 msec (females)
• •* Uncontrolled hypertension (per Investigator's discretion)
• •* Class III or IV cardiovascular disease according to the New York Heart Association's (NYHA) Functional Criteria.
• •* Myocardial infarction (MI) within 6 months prior to first study drug administration
• •8. Patients with known osteopenia or osteoporosis.
• •9. Patients with a known or suspected hypersensitivity to either gemcitabine or any of the components of PRI-724.
• •10. Patients with a history of human immunodeficiency virus (HIV) or active infection with hepatitis B virus (HBV) or hepatitis C virus (HCV).
• •11. Patients with any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever \> 38ºC within 2 weeks prior to first study drug administration.
• •12. Patients with inadequate recovery from acute toxicity associated with any prior antineoplastic therapy
• •13. Patients with inadequate recovery from any prior surgical procedure, or patients having undergone any major surgical procedure within 1 month prior to first study drug administration.
• •14. Patients with any other life-threatening illness, significant organ system dysfunction, or clinically significant laboratory abnormality, which, in the opinion of the Investigator, would either compromise the patient's safety or interfere with evaluation of the safety of the study drug
• •15. Patients with a psychiatric disorder or altered mental status that would preclude understanding of the informed consent process and/or completion of the necessary studies
• •16. Patients with the inability, in the opinion of the Investigator, to comply with the protocol requirements