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Lead
Massachusetts General Hospital
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients ages 18-70
Underlying hematological disorder which is potentially curable with allogeneic bone marrow transplantation. This includes, but is not limited to: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, multiple myeloma (MM), myelodysplastic syndrome (MDS), AL amyloidosis, diamond blackfan anemia, myelofibrosis or other myeloproliferative disease, sickle cell anemia, and thalassemia.
Existence of haploidentical first degree relative who passes standard donor evaluations for bone marrow and kidney donation
LVEF \> 40% as measured by echocardiography or MUGA
FEV1, FVC, and DLCO \> 50% of predicted as measured by standard PFTs
Total bilirubin \< 2.0 (unless diagnosis of Gilbert's or hemolysis is made) and AST, ALT, alkaline phosphatase all \< 5x institutions upper limit of normal
ABO compatibility in the host vs. graft direction
Men and women of reproductive potential must agree to use a reliable method of birth control during the treatment, and women should do so for a period of 1 year following the transplant.
Participants should be on dialysis or have an estimated or measured CrCl \< 35 ml/min
Life expectancy greater than six months.
Recipient ability to understand and provide informed consent
You may not be if
Active serious infection
Participation in other investigational drug use at the time of enrollment
Contraindication to therapy with any one of the proposed agents (e.g., history of allergy to rabbit serum in ATG)
Serologic positivity for HIV, HCV, or HbsAg positivity
ABO blood group incompatibility in the host-vs-graft direction
Active serious infection
Clareo Health | Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders
