Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
GlaxoSmithKline
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac safety monitoring. A subject with a clinical abnormality or laboratory parameters outside the reference range for the population being studied may be included only if the Investigator and the GlaxoSmithKline (GSK) Medical Monitor agree that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures
Male or female between 18 and 65 years of age inclusive, at the time of signing the informed consent
A female subject is eligible to participate if she is of
1. Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone \[FSH\] \>40 MIU/mL and estradiol \<40 pg/mL \[\<147 pmol/L\] is confirmatory)
2. Child-bearing potential and is abstinent or agrees to use one of the allowed contraception methods with a failure rate of \<1% (Oral contraceptive, either combined or progestogen alone, Injectable progestogen, Implants of etonogestrel or levonorgestrel, Estrogenic vaginal ring, Percutaneous contraceptive patches, Intrauterine device \[IUD\] or intrauterine system \[IUS\], Male partner sterilization \[vasectomy with documentation of azoospermia\] prior to the female subject's entry into the study, and this male is the sole partner for that subject, Male condom combined with a female diaphragm, either with or without a vaginal spermicide \[foam, gel, cream or suppository\], Male condom combined with a vaginal spermicide \[foam, gel, cream or suppository\]) for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until the follow-up visit
Body weight \>=50 kg and Body mass index (BMI) within the range 19 to 28 kg/m\^2 (inclusive)
Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin \<=1.5 x upper limit of normal (ULN) (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%)
You may not be if
Subjects with cardiac conduction abnormalities on the screening 12-lead ECG denoted by any of the following
1. QTcB or QTcF \>450 msec
2. PR interval \>200 msec or \<=110 msec
3. evidence of second- or third- degree atrioventricular block (AVB)
4. clinically significant pathological Q-waves (defined as Q-wave \>40 msec or depth greater than 0.4 to 0.5 mV)
5. evidence of ventricular pre-excitation
6. electrocardiographic evidence of complete left bundle branch block (LBBB), right bundle branch block (RBBB), incomplete LBBB
7. intraventricular conduction delay with QRS duration \>110 msec
8. bradycardia as defined by sinus rate \<45 beats per minute (BPM) or tachycardia as defined by sinus rate \>100 BPM
Any clinically relevant abnormality identified on the screening medical assessment, laboratory examination or ECG
Subjects with a personal or family history of QTc prolongation, symptomatic cardiac arrhythmias or cardiac arrest
History of hypersensitivity to moxifloxacin or components thereof or a history of drug or other allergy that, in the opinion of the physician responsible, contraindicates their participation
A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
A positive pre-study drug/alcohol screen
A positive test for Human immunodeficiency virus (HIV) antibody result within 3 months of screening
History of regular alcohol consumption within 6 months of the study defined as (For US sites) an average weekly intake of \>14 drinks for males or \>7 drinks for females. One drink is equivalent to 12 g of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits
The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer)
Exposure to more than four new chemical entities within 12 months prior to the first dosing day
Unable to refrain from the use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and GSK Medical Monitor the medication will not interfere with the study procedures or compromise subject safety
Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period
Pregnant females as determined by positive serum human chorionic gonadotropin (hCG) test at screening or prior to dosing
Lactating females
Unwillingness or inability to follow the procedures outlined in the protocol
Subject is mentally or legally incapacitated
History of sensitivity to heparin or heparin-induced thrombocytopenia
