A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis

Exclusion Criteria

• •1. Subject has a previous history of any clinically significant neurological, gastrointestinal, renal, hepatic, pulmonary, metabolic, cardiovascular, psychiatric, endocrine, hematological disorder or disease, or any other medical condition that would preclude participation in the study
• •2. Subject has a known history of positive test for hepatitis B surface antigen (HbsAg) or hepatitis C antibody or history of a positive test for human immunodeficiency virus (HIV) infection
• •3. Subject has received live virus vaccination within the last 30 days prior to study drug administration
• •4. Subject has a Body Mass Index (BMI) \> 35 (kg/m2)
• •5. Subject is on biologic disease modifying anti-rheumatic drug (DMARDs) therapy
• •6. Subject has a current history of anemia as defined by hemoglobin of less than 12 g/dL
• •7. Subject has a recent history (within the last 6 months) of drug or alcohol abuse or a positive urine screen for alcohol or drugs of abuse/illegal drugs at Screening or check-in
• •8. Subject has received any investigational agent within 30 days of screening