A Single Dose Study of LY2605541 in Participants With Liver Impairment

Exclusion Criteria

• •All Participants (including those with T2DM)
• •Are currently enrolled in, have completed or discontinued within the last 30 days from a clinical trial involving an investigational product, or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
• •Have an acute infection with fever or infectious disease or febrile illness within 3 days prior to administration of the study medication
• •Have known allergies or significant hypersensitivity to LY2605541, its excipients, or related compounds, or history of relevant allergic reactions of any origin
• •Have previously completed or withdrawn from this study or any other study investigating LY2605541 and have previously received the investigational product
• •Have Type 1 Diabetes Mellitus (T1DM) or have T2DM and are receiving anti-diabetic medication
• •Have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the investigator, increases the risks associated with participating in the study
• •Regularly use known drugs of abuse and/or show positive findings on urinary drug screening
• •Show evidence of human immunodeficiency virus (HIV) infection and/or positive HIV antibodies
• •Have donated blood of more than 500 milliliters (mL) within the last month
• •Have had a liver transplant or have taken immunosuppressants following any organ transplant
• •Have shown signs of variceal bleeding during the last 2 weeks prior to screening
• •Show evidence of irritable bowel syndrome, chronic diarrhea, other symptomatic digestive problems or a known history of repeated chronic stool positive for occult blood, or be considered by the investigator to be at greater risk of acute or chronic pancreatitis
• •Have an average weekly alcohol intake that exceeds 21 units per week (males) and 14 units per week (females), or are unwilling to stop alcohol consumption for the duration of the study (1 unit = 12 ounces \[oz\] or 360 mL of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits)
• •Are on total parenteral nutrition
• •Take anticoagulants for therapeutic use, other than low dose acetylsalicyclic acid
• •Are excessive consumers of xanthines
• •Participants with Normal Hepatic Function
• •Have any medically significant history of neurologic disease, cancer, or cardiac, respiratory, metabolic, hepatic, renal, gastrointestinal (except appendectomy and cholecystectomy), dermatological, venereal, hematological disorder or disease
• •Have creatinine clearance (CrCl) less than 80 milliliters per minute (mL/min)
• •Show evidence of significant active neuropsychiatric disease in the opinion of the investigator
• •Show evidence of hepatitis B and/or positive hepatitis B surface antigen
• •Show evidence of hepatitis C and/or positive hepatitis C antibody
• •Participants with Hepatic Impairment
• •Show evidence of any significant active disease other than that responsible for or associated with mild, moderate, or severe hepatic impairment
• •Show evidence of hepatorenal syndrome as shown by CrCl \<50 mL/min calculated using the Cockcroft-Gault equation
• •Have shown signs of spontaneous bacterial peritonitis within 6 months prior to enrollment into the study
• •Have severe hyponatremia (sodium \<120 millimoles per liter \[mmol/L\])
• •Show signs of hepatocellular carcinoma
• •Have a portal shunt
• •Show, in the opinion of the investigator, evidence of significant active neuropsychiatric disease other than grade 1 hepatic encephalopathy
• •Have hemoglobin concentrations \<9.0 grams per deciliter (g/dL)
• •Have a platelet count of \<30 x 10\^9 cells per liter (cells/L), unless, after consultation with the sponsor, they are considered as acceptable for participation in the study
• •Have total serum bilirubin concentrations \>15 milligrams per deciliter (mg/dL) (\>257 micromoles per liter \[μmol/L\])
• •Take medications known to interfere with hepatic metabolism (for example barbiturates or phenothiayines) or known to alter other major organ systems
• •Show signs of acute cholestasis or acute cholecystitis
• •Have severe ascites