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COMPLETEDNANCT01750723

Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brai...

Lead sponsor: Danish Headache Center•2 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Danish Headache Center

To investigate headache score and accompanying symptoms during and after infusion of acetazolamide. With magnetic resonance imaging the investigators will investigate changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), diameter of MCA, the Internal carotic artery (ICA), the superficial temporal artery (STA) and the Medial Meningeal artery (MMA).

Age

18 - 50 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy volunteers
•Aged 18-40
•50-100 kg
•Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria

•Tension type headache more than once/month
•Other primary headaches
•Daily medication except contraceptives
•Drug taken within 4 times the halflife for the specific drug except contraceptives
•Pregnant or lactating women
•Exposure to radiation within the last year
•Headache within the last 24 hours before start of trial
•Hypertension
•Hypotension
•Respiratory or cardiac disease

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: July 9, 2013Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment12

Start dateDec 2012

Last updatedJul 9, 2013

Condition

Headache Migraine

Locations shown

Danish Headache Center

Copenhagen, Glostrup

Department of Neurology

Copenhagen, Glostrup

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 9, 2013Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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