AC105 in Patients With Acute Traumatic Spinal Cord Injury

Exclusion Criteria

• •Known allergy or hypersensitivity to polyethylene glycol
• •Mental impairment or other conditions that would preclude a reliable ASIA exam or adequate consent
• •Positive urine pregnancy test result
• •Serum creatinine level ≥ 2 mg/dL
• •History or active renal failure or dialysis
• •Mean arterial blood pressure \< 60 mmHg despite vasopressor treatment
• •On a current regimen of digoxin
• •Chronic use of magnesium salts prior to the SCI (within 1week of presentation) and/or the use of magnesium salts in the acute care setting prior to the administration of investigational product
• •Any other medical condition that, in the judgment of the investigator, would preclude provision of informed consent, make participation in the study unsafe, or unreasonably complicate follow-up or the interpretation of study outcome data or may otherwise interfere with achieving the study objectives
• •In the judgment of the Investigator, cannot adequately provide informed consent, is likely to be non-compliant, or may be unable to cooperate with study requirements