Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hospices Civils de Lyon
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
All patients may have a clinically definite, laboratory-supported diagnosis of multiple sclerosis according to the Mac Donald criteria.
All patients may present a chronic acquired pendular nystagmus due to MS, observed over a period of 6 months.
All patients will be informed about the design and purpose of the study, and all will give their informed, written consent to the protocol, which may have been approved by the local ethics committee.
Age: above 18
Able to understand the instructions
Having a health coverage
Able to sit down for 1 hour
Stable dosage of previous medications (beginning 3 weeks previously and terminating at the end of the trial duration), except for steroids, gabapentin or memantine.
You may not be if
Ophthalmological
* Other ophthalmological disorder that could impair corrected visual acuity (Maculopathy, Retinopathy…)
Neurological
* Ongoing seizure
* Severe handicap that does not allow sitting down position for 1 hour
Suicidal behavior or risk
Treatment
* Under memantine or gabapentin medication (these medications should have been stopped for at least 1 week for gabapentin and 3 weeks for memantine)
* Under morphine, N-methyl-D-aspartate such as amantadine, ketamine or dextromethorphan
* Steroid medication for a current relapse (beginning 3 weeks previously and terminating at the end of the trial duration)
* Known hypersensitivity to memantine or gabapentin
General
* Unstable medical state
* Patient with a galactose intolerance, a lapp lactase deficiency or glucose-galactose malabsorption
* Moderate renal failure (creatinine clearance \< 50 mL/min on bioassay dated from less than one month)
