Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis

Exclusion Criteria

• •Ophthalmological
• •* Other ophthalmological disorder that could impair corrected visual acuity (Maculopathy, Retinopathy…)
• •Neurological
• •* Ongoing seizure
• •* Severe handicap that does not allow sitting down position for 1 hour
• •Suicidal behavior or risk
• •Treatment
• •* Under memantine or gabapentin medication (these medications should have been stopped for at least 1 week for gabapentin and 3 weeks for memantine)
• •* Under morphine, N-methyl-D-aspartate such as amantadine, ketamine or dextromethorphan
• •* Steroid medication for a current relapse (beginning 3 weeks previously and terminating at the end of the trial duration)
• •* Known hypersensitivity to memantine or gabapentin
• •General
• •* Unstable medical state
• •* Patient with a galactose intolerance, a lapp lactase deficiency or glucose-galactose malabsorption
• •* Moderate renal failure (creatinine clearance \< 50 mL/min on bioassay dated from less than one month)
• •* Recent heart infarction (\<3months)
• •* Unstable congestive heart insufficiency
• •* Unstable arterial hypertension
• •* Leucopenia (\<2500/mm3)
• •* Transaminase increase (\>5 time normal values)
• •Pregnancy (on questioning)
• •Tutelage or any legal protection measure