A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders

Exclusion Criteria

• •1. Medical disorder or psychiatric comorbidity or condition known to affect prolactin, sex hormone balance or bone metabolism (i.e., unstable medical disease, Cushing's disease, chronic renal failure, thyroid dysfunction, eating disorder)
• •2. History of hematological and/or solid malignancies
• •3. Physical or functional obstruction to food intake or impaired digestive/absorptive function
• •4. Known hypersensitivity to any study medication (risperidone, paliperidone, and aripiprazole)
• •5. Insulin requiring diabetes mellitus or poorly controlled diabetes mellitus (HbA1c \> 9% or change of antidiabetics treatment within the 12weeks prior to screening)
• •6. Uncontrolled hypertension (SBP/DBP 140/90 mmHg), congestive heart failure (NYHA class III or IV), other significant cardiovascular illness (myocardial infarction, unstable angina, cardiac arrhythmia etc.)
• •7. Baseline QTc interval of \> 450 msec
• •8. Hepatic and/or renal dysfunction
• •1\) Bilirubin level ≥ 1.5 upper normal limits 2) AST/ALT ≥ 3 UNL or 3) Serum creatinine ≥ 1.5 9. Any patient hospitalized for acute exacerbation of their condition within 2 months of randomization 10. Recent (within the past 1 month) or planned treatment with prohibited medications in the protocol
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