Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung

Inclusion Criteria

• •Patient must have a histologic diagnosis of breast or pancreatic adenocarcinoma (expansion cohort) metastatic to the liver or lung
• •Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
• •Women of child-bearing potential must have a negative serum pregnancy test within 7 days of the first DCE-MRI and must have agreed to use an effective contraceptive method; the effects of iRGD on the developing fetus are unknown; for this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation; should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• •Patient must have a measurable lesion at least 2 cm in size amenable to DCE-MRI study as determined by Radiology
• •Computed tomography (CT)/MRI scan must be obtained within 3 weeks prior to study entry
• •Absolute neutrophil count \>= 1,500/mcl
• •Platelet count \>= 100,000/mcl
• •Creatinine =\< 1.3 mg/dl or a measured creatinine clearance \>= 60 cc/min
• •Bilirubin =\< 1.5 mg/dl
• •Alanine aminotransferase (ALT), aspartate aminotransferase (AST) no greater than 2.5 times the upper limit of normal for patients with liver metastases; patients without liver metastasis should have ALT and AST no greater than 1.5 times the upper limit of normal
• •Patients currently being treated for severe infections or who are recovering from major surgery or other intercurrent illnesses are ineligible until recovery is deemed complete by the investigator
• •All subjects must have the ability to understand and the willingness to sign a written informed consent
• •Patients with grade 2 or higher toxicity due to previous chemotherapy; all toxicities should recover to grade 0 or 1 prior to day 1