ADenosine Vasodilator Independent Stenosis Evaluation II - ADVISE II

Exclusion Criteria

• •\- Known contraindication to adenosine administration
• •Implanted temporary or permanent artificial pacemakers, Left Bundle Branch Block (LBBB), 1st and 2nd degree AV Block
• •STEMI or non STEMI within 48 hours of procedure
• •Any contraindications for FFR interrogation or percutaneous coronary intervention (PCI) as determined by the investigator
• •Severe vessel tortuosity and/or severe calcification by angiogram
• •Significant valvular pathology (moderate or severe AS/AR/MS/MR)
• •Previous Coronary Artery Bypass surgery with patent grafts to the interrogated vessel
• •Weight \>200kg (441 lbs.)
• •Hemodynamic instability at the time of intervention (heart rate\<50 beats per minute, systolic blood pressure \<90mmHg) balloon pump
• •Significant hepatic disease, renal disease, lung disease (pulmonary chronic pulmonary obstructive disease) and/or malignant disease with unfavorable prognosis or presenting with abnormal serum laboratory values that the physician believes is clinically significant
• •Contraindication to antithrombotic regimen or anticoagulation therapy
• •History of or known reaction or sensitivity to contrast agent and is unable to be pre-medicated
• •Left main stenosis, tandem stenosis separated by more than 5 mm that require separate pressure guide wire interrogation or PCI (not to be interrogated or treated as a single stenosis), or total occlusions
• •Known Left ventricular ejection fraction (LVEF) \<30%