patients who received acetaminophen in the past 48 hours prior to enrollment

intolerance or allergy to acetaminophen

measured AST/ALT \>400 U/L in the 24 hours prior to enrollment

chronic liver disease defined by a Child-Pugh score \>4

cannot swallow or have no enteral feeding access

patients with no detectable cell-free hemoglobin

patients transitioned to palliative care

pregnant patients or women of childbearing potential without a documented pregnancy test

Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis