fMRI and DTI of Cerebellar Responses to Pain in the Human Trigeminal System

Exclusion Criteria

• •History of drug abuse or positive drug screen
• •Magnetic Implants of any type (including dental bridges, crowns, retainers, orthodontic devices, etc)
• •Weight \> 285 pounds (weight limit of the fMRI table)
• •Positive pregnancy screen
• •Beck Depression Inventory II (BDI-II) score \> 25 (moderate to severe depression)
• •History of primary depression, anxiety disorders, or mood disorders
• •Prolonged use of antidepressants or anticonvulsants
• •Evidence of local pathology; e.g. cancer affecting the face
• •History of systemic disorders, e.g. multiple sclerosis
• •History of chronic pain, e.g. back pain
• •History of primary headache, e.g. migraine, tension-type headache
• •Recent orofacial surgery or trauma
• •History of central origin disorders, eg. stroke
• •History of dermatological hypersensitivity in the facial area
• •History of Eczema
• •Significant medical history of seizure disorder, diabetes, cardiac disease including coronary artery disease, psychiatric problems; respiratory problems, liver disease, etc.
• •Significant alcohol history (ingestion of 5 or more glasses (\>40 oz) of alcohol per week)
• •Claustrophobia
• •Pregnancy
• •Smokers
• •Tattoos containing metallic ink on the neck, shoulders, upper arm and head (which could become heated up in the scanner, and potentially cause blistering or burning)
• •Cardiac pacemakers
• •Aneurysm clips and other vascular stents, filters, clips or other devices
• •Prosthetic heart valves
• •Other prostheses
• •Neuro-stimulator devices
• •Implanted infusion pumps
• •Cochlear (ear) implants
• •Ocular (eye) implants or known metal fragments in eyes
• •Exposure to shrapnel or metal filings (sheet metal workers, welders, and others)
• •Other metallic surgical hardware in vital areas
• •Repeated monthly usage of the ovulation test kit fails to detect a luteinizing hormone surge (for females not on contraception only)