Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria

• •Ability to walk, sit down and stand up independently
• •Age 45 years or older
• •Ability to lie in supine or elevated position for 5.5 hours
• •Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: Forced Expiratory Volume(FEV1)/Forced Vital Capacity (FVC) \< 0.70 and FEV1 \< 70% of reference FEV1
• •Clinically stable condition and not suffering from a respiratory tract infection or exacerbation of their disease (defined as a combination of increased cough, sputum purulence, shortness of breath, systemic symptoms such as fever, and a decrease in FEV1 \> 10% compared with values when clinically stable in the preceding year) at least 4 weeks prior to the first test day
• •Shortness of breath on exertion
• •Willingness and ability to comply with the protocol, including:
• •* Adhering to fasting state from 10 pm ± 2h onwards the day prior to each study visit
• •Healthy male or female according to the investigator's or appointed staff's judgment
• •Ability to walk, sit down and stand up independently
• •Age 45 years or older
• •Ability to lay in supine or elevated position for 5.5 hours
• •No diagnosis of chronic airflow limitation and compliant to the following criteria: FEV1/FVC \> 0.70 and FEV1 ≥ 80% of reference FEV1
• •Willingness and ability to comply with the protocol, including:
• •* Adhering to fasting state from 10 pm ± 2h onwards the day prior to each study visit