Argatroban in Critically Ill Patients With Heparin Resistance

Exclusion Criteria

• •If patient needs an aPTT-level \> 60 sec for any reason
• •Active bleeding
• •Risk for bleeding higher than risk of thromboembolic event as anticipated by the physician
• •Surgical procedure with the need for interruption of antithrombotic therapy within the next 24 hours
• •Inevitable lethal course
• •Severe Liver failure: Quick \< 30 %
• •Pregnancy
• •Planned peridural or spinal anaesthesia during the study
• •Patient with known refusal of a participation in this clinical trial
• •Active participation in another clinical trial
• •Any condition, including the presence of laboratory abnormalities, which would place the subject at unacceptable risk if he/she were to participate in the study or confound the ability to interpret data from the study
• •Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form