A Phase 0, Open Label, Multi-center Exploratory and Safety Study of [F-18]T807

Inclusion Criteria

• •Participant has reached his or her 55th birthday at the time of informed consent (Participant is male or female of any race / ethnicity)
• •Participant provides written informed consent
• •Participant is capable of complying with study procedures
• •Participant is capable of communicating with study personnel
• •Participant understands and speaks English
• •Participant has at least an 8th Grade education
• •In the Investigator's opinion, participant has a low probability of being currently positive for AD as determined by a Mini Mental State Examination (MMSE ≥ 28) defined in APPENDIX VI of protocol T807000, IND 114102
• •Participant has no significant hepatic or renal disease as defined by previous medical history and lab results are within the following ranges:
• •Total bilirubin within 2x institutional upper limits of normal
• •AST (SGOT) ≤ 2.5 x institutional upper limits of normal
• •ALT (SGPT) ≤ 2.5 x institutional upper limits of normal
• •Creatinine ≤ 2x institutional upper limits of normal
• •BUN within 2x institutional upper limits of normal
• •High Probability for AD Participants (Group 2)
• •Participant has reached his or her 55th birthday at the time of informed consent (Participant is male or female of any race / ethnicity)
• •Participant or participant's legally acceptable representative provides written informed consent
• •Participant is capable of complying with study procedures
• •Participant is capable of communicating with study personnel
• •Participant understands and speaks English
• •Participant has at least an 8th Grade education
• •In the Investigator's opinion, participant has a high probability of being currently positive for AD that is determined by a Mini Mental State Examination (MMSE \< 17) defined in APPENDIX VI of protocol T807000, IND 114102.
• •Participant has no significant hepatic or renal disease as defined by previous medical history, and lab results are within the following ranges:
• •Total bilirubin within 2x institutional upper limits of normal
• •AST (SGOT) ≤ 2.5 x institutional upper limits of normal
• •ALT (SGPT) ≤ 2.5 x institutional upper limits of normal
• •Creatinine ≤ 2x institutional upper limits of normal
• •BUN within 2x institutional upper limits of normal