Lead Sponsor

Pfizer

Age

18 - 90 years

Sex

ALL

Healthy Volunteers

No

•Patient must be 18 to 90 years of age, inclusive,
•Female patients can participate if they are surgically sterilized or postmenopausal for at least 1 year or her sexual partner has had a vasectomy
•Female of childbearing potential has had normal menstrual periods for 3 months and negative serum pregnancy test and agree to practice highly effective methods of birth control during treatment and for at least 7 days after last dose
•Intraoperative/postoperative enrollment with visual confirmation (presence of pus within the abdominal cavity) of an intra-abdominal infection associated with peritonitis
•Confirmation of infection by surgical intervention within 24 hours of entry: evidence of systemic inflammatory indicators; physical findings consistent with intra-abdominal infection; supportive radiologic imaging findings of intra-abdominal infections

•Patient is diagnosed with traumatic bowel perforation undergoing surgery within 12 hours; perforation of gastroduodenal ulcers undergoing surgery within 24 hours. Other intra-abdominal processes in which primary etiology is not likely to be infectious
•Patient has abdominal wall abscess or bowel obstruction without perforation or ischemic bowel without perforation
•Patients whose surgery will include staged abdominal repair, or "open abdomen" technique, or marsupialization
•Patient has suspected intra-abdominal infections due to fungus, parasites, virus or tuberculosis
•Patient is considered unlikely to survive the 6- to 8-week study period or has a rapidly progressive or terminal illness, including septic shock that is associated with a high risk of mortality

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