Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET

Exclusion Criteria

• •1. Are currently enrolled in, or discontinued within the last \[30 days\] from, a clinical trial involving an off-label use of an investigational drug or device, or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study.
• •2. Current substance abuse (other than AD) including marijuana use, or severe systemic disease based on history and physical exam.
• •3. Laboratory tests with clinically significant abnormalities or positive urine toxicology screen. (Note: specific laboratory tests are listed in section 3.4)
• •4. Prior participation in other research protocols in the last year such that radiation exposure would exceed the annual limits.
• •5. Presence of ferromagnetic metal in the body or heart pacemaker.
• •6. Are persons who have previously completed or withdrawn from this study or any other study investigating \[C-11\]OMAR.
• •7. Regularly use known drugs of abuse (other than alcohol) within 30 days of the study and/or show positive findings on urinary drug screening.
• •8. Show evidence of human immunodeficiency virus (HIV) and/or positive human HIV antibodies.
• •9. Are women with a positive pregnancy test or women who are lactating.
• •10. Have a history of head trauma with prolonged loss of consciousness (\>10 minutes), or any neurological condition including stroke or seizure (excluding a single childhood febrile seizure) or a history of migraine headaches
• •11. History of adverse drug reactions or intolerance to more than three types of systemically administered medications
• •12. Have used any prescription medication (except for oral contraceptives or hormone replacement therapy) or over-the-counter medication (including herbal remedies or diet aids) within 14 days of the imaging session. Multiple vitamins are specifically permitted
• •13. Have implanted or embedded metal objects or fragments in the head or body that would present a risk during the MRI scanning procedure, or have worked with ferrous metals either as a vocation or hobby (for example, as a sheet metal worker, welder, or machinist) in such a way that might have led to unknown, indwelling metal fragments that could cause injury if they moved in response to placement in the magnetic field
• •14. Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits