Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)

Inclusion Criteria

• •Inclusion
• •Women aged 18 - 40, desiring pregnancy
• •Established diagnosis of PCOS confirmed by the Rotterdam criteria
• •Oligo or anovulatory, with menstrual cycles \> 35 days apart or less than 9 menstrual cycles per year
• •Normal vaginal ultrasound with endometrial stripe \< 12 mm
• •Normal thyroid stimulating hormone (TSH) within past one year
• •Normal prolactin (PRL) within past one year
• •For women with previous successful Clomid treatment, a washout period of at least 2 months is required
• •Exclusion
• •Regular menstrual cycles occurring less than 35 days apart
• •Evidence of other infertility factors such as endometriosis, tubal factor or male infertility
• •Prior unsuccessful Clomiphene citrate ovulation cycles
• •Abnormal vaginal ultrasound findings such as endometrial polyps, submucous myomas, synechiae
• •Uterine anomaly such as unicornuate or bicornuate uterus
• •Presence of hydrosalpinx
• •Evidence of active endocrinopathy, such as thyroid disorder or hyperprolactinemia
• •Partner with abnormal semen analysis (count \< 15 million sperm /ml)