Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)

You may be eligible if

• Inclusion
• Women aged 18 - 40, desiring pregnancy
• Established diagnosis of PCOS confirmed by the Rotterdam criteria
• Oligo or anovulatory, with menstrual cycles \> 35 days apart or less than 9 menstrual cycles per year
• Normal vaginal ultrasound with endometrial stripe \< 12 mm
• Normal thyroid stimulating hormone (TSH) within past one year
• Normal prolactin (PRL) within past one year
• For women with previous successful Clomid treatment, a washout period of at least 2 months is required
• Exclusion
• Regular menstrual cycles occurring less than 35 days apart
• Evidence of other infertility factors such as endometriosis, tubal factor or male infertility
• Prior unsuccessful Clomiphene citrate ovulation cycles
• Abnormal vaginal ultrasound findings such as endometrial polyps, submucous myomas, synechiae
• Uterine anomaly such as unicornuate or bicornuate uterus
• Presence of hydrosalpinx
• Evidence of active endocrinopathy, such as thyroid disorder or hyperprolactinemia
• Partner with abnormal semen analysis (count \< 15 million sperm /ml)