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The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients | Clinical Trials | Clareo Health

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The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients

NCT01711996•Yonsei University

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Summary

Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of hydronephrosis in pediatric ureteropelvic junction obstruction (UPJO) patients. We are trying to analyze whether it is related with the grade of renal injury in UPJO patients.

Eligibility

Age

0 - 3 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•\<Group 1\>
•1. 0-3 year old patients with SFU grade 2 or more hydronephrosis without ureteral dilatation
•2. needs pyeloplasty due to differential renal function (DRF)\<40%, decreased DRF by more than 5%, development of urinary tract infection, development of urinary stone, and development of pain related with UPJO \<Group 2\>
•1\. 0-3 year old patients with SFU grade 3 or 4 hydronephrosis without ureteral dilatation 2. doesn't meet the above criteria for the indication of pyeloplasty \<Group 3\>
•1\. 0-3 year old children without any abnormality of urinary tract

Exclusion Criteria

•\<Group 1\>
•1. patients with contralateral disease affecting DRF
•2. history of previous urinary tract surgery
•3. follow up loss before diuretic renogram performed at 6-12 months from operation \<Group 2, 3\>
•1\. patients with contralateral disease affecting DRF 2. history of previous urinary tract surgery

Locations (1)

Department of Urology, Urological Science Institute, Yonsei University, Colleage of Medicine

Seoul, South Korea

Key Dates

Start Date

August 1, 2012

Primary Completion Date

August 1, 2012

Completion Date

August 1, 2013

Last Updated

May 6, 2021

Conditions

Ureteropelvic Junction Obstruction

Ultrasound Localization Microscopy in Patient With Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

NCT06921733

Congenital Anomalies of Kidney and Urinary TractLower Urinary Tract Obstruction, Congenital+2 more

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RECRUITINGNA

CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome

NCT02812212

Ureteropelvic Junction Obstruction

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 6, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients

Inclusion Criteria

Exclusion Criteria

Ultrasound Localization Microscopy in Patient With Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome

Comparison Between Classic Laparoscopic Dismembered Pyeloplasty and Insitu Spatulation with Pre-Dismembering Ureteropelvic Angle Suturing.

Ureteropelvic Junction Obstruction in Early Childhood: Comparison of Surgical Therapy and Surveillance. A Prospective, Randomized, Controlled Multi-Center Study