Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain

Inclusion Criteria

• •Diagnosis of osteoarthritis (OA) of the knee
• •OA knee pain present for at least 3 months
• •OA knee pain is the predominant (ie, most painful) pain condition
• •Patients require medication on at least 4 of 7 days per week to treat OA knee pain for at least 1 month.
• •Dissatisfaction with current OA knee pain treatment and willingness to stop taking all pain medications except for the study drug and allowed rescue medication
• •Average daily pain rating of at least 5 on a 0 to 10 point numerical rating scale during the 1 week prior to randomization
• •Female patients either postmenopausal, surgically sterile or practicing a medically acceptable method of contraception
• •Male patients either status post-bilateral vasectomy or using barrier contraception