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The primary objective is to develop a rapid in vitro screening assay for detection of pancreatic cancer biomarkers in blood of patients with pancreatic cancer.
The goal of the project is to develop a rapid in vitro screening assay for detection of cancer biomarkers in blood. The aim is testing and optimization of nanoparticle sensors, based on cyanine dyes that are chemically linked to Fe/Fe3O4 nanoparticles via protease-selective consensus (cleavage) sequences. The focus is on the quantitative determination of active cancer-specific proteases in blood via simple fluorescence measurements. The matrix metalloproteinases, urokinase-type plasminogen activator, and cathepsins, are up-regulated in the vast majority of progressing cancers and can, therefore, serve as markers for cell survival/tumor progression, angiogenesis, and tissue remodeling/invasion
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Start Date
October 1, 2012
Primary Completion Date
February 1, 2013
Completion Date
February 1, 2013
Last Updated
May 16, 2013
Lead Sponsor
University of Kansas
NCT04550494
NCT05053971
Data Source & Attribution
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