Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Gilead Sciences
With
National Institute of Allergy and Infectious Diseases (NIAID)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
HIV-infected individuals must have positive serologies with viral load suppressed below 400 copies/mL
HCV-infected individuals must have:
* Chronic HCV infection with HCV RNA ≥ 2000 IU/ml AND at least 1 of the following:
* Been null responder to previous pegylated interferon and ribavirin therapy OR
* Failed to achieve sustained virologic response (SVR) on a regimen containing a direct-acting antiviral (DAA) in addition to pegylated interferon and ribavirin OR
* Are unwilling to receive or have contraindications to interferon therapy for HCV
HIV/HCV co-infected individuals must have:
* Positive HIV serologies with viral load suppressed below 400 copies/mL
* Chronic HCV infection with HCV RNA ≥ 2000 IU/ml AND at least 1 of the following:
* Been null responder to previous pegylated interferon and ribavirin therapy OR
* Failed to achieve SVR on a regimen containing a direct-acting antiviral (DAA) in addition to pegylated interferon and ribavirin OR
* Are unwilling to receive or have contraindications to interferon therapy for HCV
Willing to allow blood and tissue samples to be stored for future use to study HIV infection, immune function, liver disease and additional mechanisms involved in liver fibrosis among patients with HIV and/or HCV, which may not be related directly to the specific objectives of this study protocol
Have a primary care physician
You may not be if
Cause of liver fibrosis other than HCV or long-term antiretroviral therapy (ART) treatment for HIV
Currently being treated for HCV
Evidence of active Hepatitis A, B or D infections
History or evidence of hepatocellular carcinoma
Unwillingness to undergo a liver biopsy pre-treatment and post-treatment, or to undergo all other protocol required tests/procedures or return to the site for required visits
Presence of contraindications to magnetic resonance imaging (e.g., presence of any metal in the body, cardiac or neural pacemaker, aneurysm clip, cochlear implant, claustrophobia)
