Feasibility Study of Genomic Profiling Methods and Timing in Tumor Samples

Inclusion Criteria

• •Age ≥ 18 years.
• •Histological or cytological proof of either metastatic breast, colorectal, gynecological or melanoma malignancy.
• •At least one biopsiable lesion deemed medically accessible and safe to biopsy.
• •Candidate for one or more phase I or II clinical trials at the time of study enrollment or at a later time point.
• •Fulfills local institution's laboratory parameters for tumor biopsy.
• •Willingness and ability of patient to provide signed voluntary informed consent.