A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma

Inclusion Criteria

• •For Part A: Have a diagnosis of recurrent or refractory rhabdomyosarcoma or medulloblastoma and have had histologic verification of malignancy at original diagnosis or relapse.
• •For Part B: Have a diagnosis of recurrent or refractory medulloblastoma and have had histologic verification of malignancy at original diagnosis or relapse.
• •Current disease state must be one for which there is no known curative therapy or therapy proven to prolong survival with an acceptable quality of life.
• •Karnofsky score must be at least 50% for participants \>16 years of age, and Lansky score must be at least 50% for participants 16 years of age or less. Participants who are unable to walk because of paralysis, but who are in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score.
• •Have fully recovered from the acute toxic effects of all prior anticancer chemotherapy.
• •* Participants with solid tumors must not have received myelosuppressive chemotherapy within 3 weeks of enrollment in this study (6 weeks, if previously treated with nitrosourea).
• •* Hematopoietic growth factors: At least 14 days after the last dose of a longacting growth factor (eg, Neulasta®) or 7 days for short-acting growth factor.
• •* Biologic (antineoplastic agent): At least 7 days after the last dose of a biologic agent.
• •* Immunotherapy: At least 6 weeks since the completion of any type of immunotherapy (eg, tumor vaccines).
• •* Monoclonal antibodies: At least 3 half-lives of the antibody after the last dose of a monoclonal antibody.
• •* Radiation therapy (XRT): ≥8 weeks for local irradiation to primary tumor;≥2 weeks prior to study entry for focal irradiation for symptomatic metastatic sites; ≥3 months for craniospinal XRT, or ≥24 weeks if ≥50% radiation of pelvis; minimum of 6 weeks must have elapsed if other substantial bone marrow radiation has been received.
• •* Stem cell transplant: allowed if they have recovered from all acute toxicity and adequate bone marrow reserve is demonstrated. At least 8 weeks must have elapsed since autologous stem cell transplantation or ≥3 months for allogenic transplantation. Participants must be off all immunosuppressive therapy and have no evidence of active graft-versus-host disease.
• •Have adequate organ function, including:
• •* Bone marrow: Peripheral absolute neutrophil count (ANC) ≥500/cubic millimeter (mm\^3) and platelet count ≥100,000/mm\^3 (transfusion independent, defined as not receiving platelet transfusions within a 7-day period prior to enrollment).
• •* Hepatic: Bilirubin (sum of conjugated + unconjugated)≤1.5 × upper limit of normal (ULN) for age. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.0 times ULN for age. Serum albumin ≥2 grams/deciliter (g/dL).
• •* Renal: Creatinine clearance or radioisotope glomerular filtration rate (GFR)
• •≥70 milliliters/minute/1.73 square meters (mL/min/1.73 m\^2), or a serum creatinine based on age/gender per the Schwartz formula for estimating GFR utilizing child length and stature data published by the Centers for Disease Control and Prevention (CDC).
• •* Neurologic: Participants with seizure disorders may be enrolled if receiving nonenzyme-inducing anticonvulsants and if the symptoms are well controlled. They must have a stable neurologic status for at least 1 week prior to enrollment in the study.
• •Must be able to swallow powder or a capsule.
• •Have the presence of either measurable or nonmeasurable disease.