The Effects of Vitamin D on Glycemic Control and Proinflammatory Markers in Adolescents With T1DM

Exclusion Criteria

• •1. Less than 13 or greater than 21 years of age
• •2. Less than Tanner stage 4 sexual maturity for males or pre-menarche
• •3. HbA1c less than 7% or greater than 9%
• •4. T1DM for less than 1 year
• •5. Vitamin D sufficient (25-OH vit D level \> 30 ng/mL)
• •6. Currently taking any medication that can interfere with vitamin D synthesis or metabolism, including but not limited to Orlistat, Phenobarbital, Dilantin, Anti-tuberculosis drugs
• •7. Currently taking any medication other than insulin that alters blood glucose levels, including but not limited to systemic glucocorticoids
• •8. Inadequate renal function (serum creatinine \> 1.5mg/dL in males and \> 1.2mg/dL in females) or inadequate liver function (AST and ALT \> 2.5 times the upper limit of normal)
• •9. Evidence of malabsorption or short gut.