SGI-110 in Combination With Carboplatin in Ovarian Cancer

Inclusion Criteria

• •1. Participants who are women 18 years of age or older.
• •2. Participants who have histologically or cytologically confirmed recurrent high-grade serous epithelial ovarian cancer (Grade 2 or 3), primary peritoneal carcinomatosis or fallopian tube cancer.
• •3. Participants who have platinum-resistant disease (defined as having relapsed within 6 months of her last platinum-containing regimen). There is no limit on the number of prior treatment regimens in Part 1. In Part 2, participants may have had no more than 3 prior cytotoxic treatment regimens, excluding adjuvant or maintenance therapy.
• •4. Participants must have had prior paclitaxel treatment.
• •5. Participants who have measurable disease according to RECIST v1.1 or detectable disease.
• •6. Participants with ECOG performance status of 0 or 1.
• •7. Participants with acceptable organ function.
• •8. Participants must be at least 3 weeks from last chemotherapy.